HLA COVID-19

A centralized resource designed to support and combine efforts underway to study the association between HLA and COVID-19 infection and symptoms.

Background

  • While little is currently known about the impact of host genetic factors on the risk for infection, morbidity and mortality in COVID-19, the epidemiology to-date reveals wide variation in disease course among confirmed cases of infection that does not appear to be fully explained by known comorbidities and other risk factors. The major genetic contribution of the human leukocyte antigen (HLA) region to disease risk has been recognized for nearly fifty years, with hundreds of associations observed in autoimmunity, infectious disease, cancer, and major drug-hypersensitivities. Because of its pivotal role in the immune response to pathogens, we expect that HLA variation will also play a role in COVID-19.
  • Vast amounts of genetic data for COVID-19 risk will be emerging in the coming months, both HLA-specific and genome-wide. Because the complexity and extreme polymorphism of the HLA region make consolidation, equivalency, analysis, and biological interpretation of HLA data challenging, it is our view that a centralized resource designed to aggregate these data from disparate sources and platforms and provide well-curated bioinformatics and analytical tools will serve to accelerate discovery.

COVID-19 HLA and Immunogenetics Consortium

We are consortium of HLA and immunogenetics-focused academic research scientists, HLA clinical laboratory directors, leaders of the major international immunogenetics scientific societies, editors of HLA and immunogenetics-focused journals and commercial vendors with HLA laboratory and bioinformatics products.

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JILL HOLLENBACH

Associate Professor, Department of Neurology, UCSF, San Francisco, USA

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STEVE MACK

Associate Professor, Department of Pediatrics, UCSF, Oakland, USA

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MARTIN MAIERS

Vice President for Innovation, NMDP, Minneapolis, USA

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DANILLO G. AUGUSTO

Assistant Researcher, Department of Neurology, UCSF, San Francisco, USA

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PAUL NORMAN

Associate Professor, Division of Biomedical Information and Personalized Medicine, Anschutz Medical Campus, Denver, USA

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ALEXANDER SCHMIDT

Chief Executive, DKMS, Tubingen, Germany

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JURGEN SAUTER

Head of Scienctific Project Department, DKMS, Tubingen, Germany

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DIANNE DE SANTIS

Senior Scientist in Charge, Pathwest Laboratory, Perth, Australia

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NARINDER MEHRA

Head of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, New Delhi

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JOHANNES SCHETELIG

Head DKMS Clinical Trials Unit, Dresden, Germany

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KATSUSHI TOKUNGAWA

Director, Genome Medical Science Project-Toyama, Director, National Center Biobank Network (NCBN), National Center for Global Health and Medicine (NCGM), Tokyo, Japan

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SEBASTIAAN HEIDT

Chair of 18th International HLA & Immunogenetics Workshop, Leiden, Netherlands

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ERIC SPIERINGS

Chair of 18th International HLA & Immunogenetics Workshop, Utrecht, Netherlands

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AMY HAHN

Editor in Chief, Human Immunology, Albany, USA

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FRANS CLAAS

Director, Eurotransplant Reference Laboratory, Leiden, Netherlands

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RONALD BONTROP

Director, Editor in Chief, Immunogenetics, Biomedical Primate Research Centre, Utrecht, Netherlands

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RAJALINGHAM RAJA

Director, Immunogenetics and Transplantation Laboratory, UCSF, San Francisco, CA

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EFFIE PETERSDORF

Madeline Dabney Adams Endowed Chair in AML Research, Fred Hutch, Seattle, USA

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ATTILA BÉRCES

Founder and Chairman, Omixon, Hungary

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DAVID SAYER

Vice President, Global Transplant Laboratory Solutions,Vice President, Transplant Laboratory Solutions, CareDx

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PATRICIA MARTINEZ

Head of Immunology, PathWest FSH Network

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PETER PARHAM

Professor, Structural Biology and Microbiology and Immunology, Stanford University School of Medicine

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LISBETH A. GUETHLEIN

Department of Structural Biology and of Microbiology and Immunology, Stanford University School of Medicine

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MARCELO A. FERNÁNDEZ-VIÑA

Director, Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Professor, Department of Pathology, Stanford University School of Medicine

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ANNETTE M. JACKSON

Associate Professor, Surgery & Immunology Director, Clinical Transplantation Immunology Laboratory, Duke University School of Medicine

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ZACHARY ANTOVICH

General Manager, Transplant & Transfusion Diagnostics, Thermo Fisher Scientific

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WILLIAM H. HILDEBRAND

President-elect of ASHI, Professor, University of Oklahoma, Director, HLA Typing Laboratory

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REID THOMPSON

Assistant Professor, Department of Radiation Medicine, Biomedical Engineering, Computational Biology Program, Oregon Health & Science University, Portland, USA, Staff Physician, VA Portland Healthcare System

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ALICIA SANCHEZ-MAZAS

Full professor, Department of Genetics and Evolution - Anthropology Unit, University of Geneva, Switzerland

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SOPHIE LIMOU

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CLARA GORODESKY

Fundación Comparte Vida, A.C., Director of the Laboratory of Immunology & Immunogenetics

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STEVEN GE MARSH

Director of Bioinformatics, Anthony Nolan Research Institute & Professor of Immunogenetics, University College London

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Kelley MK Hitchman

Assistant Professor, UT Health San Antonio Long School of Medicine, Department of Pathology and Laboratory Medicine, HLA Laboratory Director, University Health System and University Hospital, San Antonio, TX

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DELORDSON KALLON

Clinical Transplantation Laboratory, Barts Health NHS Trust

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MICHAEL GAUTREAUX

Wake Forest School of Medicine

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MICHAEL HEUER

UC Berkeley

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SOPHIE LIMOU

Nantes University

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YUNG-TSI BOLON

Director, Bioinformatics Research at Be The Match, National Marrow Donor Program

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PIERRE-ANTOINE GOURRAUD

Nantes University

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ALEX JOHNSON

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DEREK MIDDLETON

Director of Operations, Allele Frequencies Net Database

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GORDON HILL

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JONATHON DOWNING

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NICOLAS VINCE

Nantes University

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RICHARD M. SINGLE

Associate Professor, Department of Mathematics and Statistics, University of Vermont

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DIOGO MEYER

Universidade de São Paulo

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JOANNIS MYTILINEOS

President, European Federation for Immunogenetics

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MAISA LOKKI

Haartman Institute

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MARIA BETTINOTTI

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MARY CARINGTON

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MEDHAT ASKAR

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RHONDA HOLDSWORTH

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SALLY ELFISHAWI

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SIAMAK BAHRAM

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MARCOS LOÓPEZ CASILLAS

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CORNELIEKE RÖELL

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BEN MATERN

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CHIA-JUNG 'JOHN' CHANG

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JOSE NUNES

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KAZU OSOEGAWA

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ERIC WEIMER

UNC Chapel Hill

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JULIANA LISZIEWICZ

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ANNE-MARGARET LITTLE

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WALEED ABDELMAGUID

Visiting Scholar, Opthalmology Department, Wexner Medical Center, Faculty of Medicine, The Ohio State University

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STEPHANIE GRAS

Assistant Professor, Monash University

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LORI J WEST

University of Alberta

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ERICK CASTELLI

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VITOR AGUIAR

University of São Paulo

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KELLY NUNES

Universidade de São Paulo

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RAJESH SIVAPRAKASAM

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FRANK CHRISTIANSEN

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RAM MOHAN JAISWAL

Mahatma Gandhi Medical College,Jaipur,India

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PAWINEE KUPATAWINTU

National Blood Centre and Thai National Stem Cell Donor Registry, Thai Red Cross Society

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STEPHEN LESLIE

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SANDEEP K. DHANDA

Saint Jude Children's Research Hospital, Memphis, TN, USA

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CHRISTINE HEYLEN

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UMA KANGA

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ANNE HALPIN

University of Alberta

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BRIAN TAIT

Haplomic Technologies

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ASAAD TAGELDEIN IDRIS ABDELHALIM

Clinical Immunology council, Sudan Medical Specialization Board

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GIOVANNA DEL POZZO

Senior CNR Researcher, Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR

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TED KANDELL

Open Genomes Foundation

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COREY WATSON

University of Louisville School of Medicine

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ESTEBAN ARRIETA-BOLANOS

UK-Essen

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CHANG-YI LIN

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CHARLES KHOR

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NATTIYA HIRANKARN

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JANETTE KWOK

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DAVE ROELEN

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CHRIS HAMMER

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WIESŁAW BABIK

Jagiellonian University, Kraków, Poland

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WENZHONG XIAO

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TOBIAS LENZ

Max Planck Institute for Evolutionary Biology, Ploen, Germany

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RICHARD CASEY

The Sequencing Center

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DAVID LANGTON

ExplantLab and National Health Service

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BRYAN HOGLUND

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NANCY GROSSMAN

Open Genomes

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KATRINA EATON

UCSF

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MÉLENIE DIEUDÉ

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SEAN MADDEN

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ABHINAV NELLORE

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ANAJANE SMITH

North Texas Genome Center, University of Texas Arlington

LET'S WORK TOGETHER